學經歷

現職

國立陽明交通大學  教育部部定  教授

臺北榮民總醫院  骨骼肌肉腫瘤研究中心  主任

臺北榮民總醫院  骨科部  關節重建科  主任

中華民國骨肉癌關懷協會  理事長

亞太骨腫瘤會議 理事

國際惡性骨腫瘤暨肢體保留學會(ISOLS) 會員

骨骼肌肉腫瘤研習營 講師

亞太關節重建醫學會(APAS) 會員

經歷

美國梅約醫學中心（Mayo Clinic）骨腫瘤中心  訪問學者 

美國梅約醫學中心（Mayo Clinic）關節重建科  訪問學者 

美國梅約醫學中心（Mayo Clinic）生物組織工程實驗室  研究員 

日本金澤大學（Kanazawa University）  臨床研究員 

臺中榮民總醫院主治醫師 

臺北榮民總醫院總醫師 

臺北榮民總醫院住院醫師


 

學歷

國立陽明交通大學臨醫所  醫學博士 

國立陽明交通大學 醫學系

教師資格

國立陽明交通大學 教育部部定 專任教授 

國立國防醫學院醫學系 臨床助理教師


 

專利

生物性冷凍裝置

治療腫瘤組合物 

冷凍處理中保護生物組織的防凍劑及其製備方法

小粒徑聚乙二醇化微脂體及其製備方

得獎紀錄

全球骨腫瘤大會 (ISOLS)  Flash Presentation 第一名, 2019  

臺北榮民總醫院 醫療創新獎, 2019 

中華民國骨科醫學會優秀論文比賽第一名, 2016

中華民國骨科醫學會優秀論文比賽佳作, 2016

中華民國骨科醫學會優秀論文比賽第一名, 2007

 骨骼肌肉腫瘤治療

惡性骨瘤切除

肢體保留手術  

生物性重建手術

良性骨腫瘤切除

惡性軟組織腫瘤切除

良性軟組織腫瘤切除

癌症合併骨轉移

冷凍治療

退化性關節炎治療

微創人工膝關節置換

微創人工髖關節置換

反轉式人工肩關節置換

人工膝關節再置換手術

人工髖關節再置換手術

國外醫學會

  • 2022-09-01
    LA, USA,美國, International Society of Limb Salvage
    Outcome of High-Grade Osteosarcoma Involving the Limbs Treated by Pedicle-Freezing Using a Novel Freezing Tank

    Biomechanical analysis and design method for patient-specific reconstructive implants for large bone defects of the distal lateral femur

    Genetic mutations related to chemosensitivity of osteosarcoma by next generation sequence analysis

    Perioperative complications of freezing nitrogen ethanol composite in treating bone tumors: Clinical experience from a single-center

    A Cryoprotectant-Gel Composite Designed to Preserve Articular Cartilage during Frozen Osteoarticular Autograft Reconstruction for Malignant Bone Tumors: An Animal Based Study
  • 2019-10-01
    Athen, Greece,希臘, International Society of Limb Salvage
    Comparative proteomic profiling and identification of significant markers from high-grade osteosarcoma after cryoablation and irradiation

    Pedicle Freezing by “Freezing Tank” for biological reconstruction of limb sarcoma

    Intraoperative extracorporeal irradiation and frozen treatment on tumor-bearing autografts show equivalent outcomes for biologic reconstruction （First Award !!!）

    The role of Frozen-Nitrogen-Ethanol-Liquid-Composite in Metal-implant-related infections. Shinning a New light on Biofilm-eradication

    Efficacy validation of freezing range and temperature conductivity of repeated cryotherapy with liquid nitrogen as adjuvant therapy for bone tumor

    Adjuvant local tumor ablation with freezing nitrogen ethanol composite: A short-term follow-up

    Patellar cryo-free technique with recycled frozen autograft reconstruction may be a better alternative to preserve the extensor mechanism for malignant proximal tibial bone tumors
  • 2019-10-01
    India, Jaipur, 印度 齋浦爾, Asia Pacific Musculoskeletal Tumour Society, 12th
    Comparative study between Allograft & Recycled Autografts for Biological Reconstruction of High-grade Osteosarcoma.

    Comparison of the Activity Preservation for BMP between ECIR- and Freezing- Treated Autografts Used for Biological Reconstruction.

    Safety and Efficacy Validation of Patella Cryo-free Method during Recycled Frozen Autograft Procedure for Proximal Tibia Malignant Bone Tumors
  • 2018-10-13
    Guatemala, Guatemala, 瓜地馬拉, Congtrso Multimedica Interisciplinaria city,
    Biological Reconstruction for Bone Sarcoma

    Cryotherapy for Benign Bone Tumor
  • 2017-10-01
    Japan, Kanazawa, 日本金澤, International Society of Limb Salvage
    Cryotherapy for Giant Cell Tumor of Bone (GCT) by Freezing Nitrogen Ethanol Composite (FNEC): Animal study.

    Activity of bone morphogenetic protein-2 after treatment by biological reconstruction.

    Comparative study between allograft and recycled autografts for biological reconstruction of high-grade Osteosarcoma.
  • 2016-10-01
    China, Beijing, 中國北京, Chinese Orthopaedic Association
    Comparative study between allograft and recycled autografts for biological reconstruction of high-grade Osteosarcoma.

    Use of a novel Freezing Nitrogen Ethanol Composite (FNEC) as adjuvant cryotherapy for treating giant cell tumor of bone (GCT)
  • 2015-10-01
    USA, Orlando, 美國奧蘭多, International Society of Limb Salvage
    Freezing Nitrogen Ethanol Composite (FNEC), a new effective cryoablation technology as an adjuvant modality treatment for giant cell tumor of bone.

    Effect of Composite Gel Cryoprotectant on Cryopreservation of Cartilage Tissues during Biological Reconstruction with Frozen Osteochondral Autograft.

    Skeletally immature child with osteogenic sarcoma over proximal femur treated with adult humeral osteochondral allograft.

    Patella Cryoprotection During Liquid Nitrogen Freezing in Limb-salvage Procedure of Proximal Tibia Bone Tumors.
  • 2014-10-01
    Australia, Sydney, 澳洲雪梨, Asia Pacific Musculoskeletal Tumour Society
    Compared Bone Prosthesis Composite and Cement-spacer Prosthesis Composite Reconstruction after Resection Proximal Humerus Malignancy.

    Cryoprotectant Could Protect Bone and Cartilage Tissue in Biological Reconstruction by Recycled Frozen Autograft.

    Cryotherapy of a Sub-trochanteric Pathologic Fracture in a patient with Gorham-Stout disease.
  • 2013-10-01
    U.S.A, Chicago, 美國芝加哥, American Academy of Orthopaedic Surgeons, AAOS
    The Prognosis of Patients with Primary Osteosarcoma Who Have Undergone Unplanned Therapy.
  • 2013-10-01
    Italy, Bologna, 義大利波隆那, International Society of Limb Salvage
    Simultaneous Anterior and Posterior Synovectomies for Treating Diffuse Pigmented Villonodular Synovitis.

    Bone and Rotating-Hinge Prosthesis Composite Reconstruction after Resection of Meta-epiphyseal Sarcoma of the Knee.

    The Prognosis of Patients with Primary Osteosarcoma Who Have Undergone Unplanned Therapy.
  • 2012-10-01
    Singapore, 新加坡, Asia Pacific Musculoskeletal Tumour Society
    The Prognosis of Patients with Primary Osteosarcoma Who Have Undergone Unplanned Therapy.
  • 2011-10-01
    China, Beijing, 中國北京, International Society of Limb Salvage
    The effect of manipulative therapy for osteosarcoma: A clinical and animal study.
  • 2010-10-01
    India, New Delhi, 印度新德里, Asia-Pacific Arthroplasty Society Annual Meeting
    Prophylaxis in Pulmonary Embolism After Total Joint Replacement.
  • U.S.A, Boston 美國波士頓, International Society of Limb Salvage
    Hemicortical Resection and Bone Graft Reconstruction for High Grade Osteosarcoma.

    Epiphyseal preservation and biological reconstruction in high-grade osteosarcoma of the knee.

    Grafting for Bone Defects after Curettage of Non-aggressive Benign Bone Tumors - Analysis of Factors Influencing the Bone healing.

    Innovative trident fixation technique for allograft knee arthrodesis for high grade osteosarcoma around the knee.
  • 2007-10-01
    German, Hamburg 德國漢堡, International Society of Limb Salvage
    Prognostic Analysis in Patients of Primary Osteogenic Sarcoma With Previous Traditional Therapy.
  • 2005-10-05
    Korea, Soul 韓國首爾, International Society of Limb Salvage
    Prognostic Factors in Primary High-Grade Osteosarcoma.
編輯器

SCI 醫學文章

  • 2021-12-31
    2021 SCI 醫學文章
    Impact of screening COVID-19 on orthopedic trauma patients at the emergency department: A consecutive series from a level I trauma center. J Chin Med Assoc. 2021 Apr 1;84(4):423-427. doi: 10.1097/JCMA.0000000000000503.

    An opioid-sparing protocol with intravenous parecoxib can effectively reduce morphine consumption after simultaneous bilateral total knee arthroplasty. Sci Rep. 2021 Apr 1;11(1):7362. doi: 10.1038/s41598-021-86826-7.

    Outcomes of dual-mobility total hip arthroplasty versus bipolar hemiarthroplasty for patients with femoral neck fractures: a systematic review and meta-analysis. J Orthop Surg Res. 2021 Feb 24;16(1):152. doi: 10.1186/s13018-021-02316-6.J Orthop Surg Res. 2021 Feb 24;16(1):152. doi: 10.1186/s13018-021-02316-6.

    Cementation of the highly cross-linked polyethylene liner into a well-fixed acetabular shell to treat patients with recurrent dislocation after total hip arthroplasty. Artif Organs. 2021 May;45(5):E136-E145. doi: 10.1111/aor.13852. Epub 2020 Dec 16.
  • 2020-12-31
    2020 SCI 醫學文章
    Total elbow arthroplasty in patients with rheumatoid arthritis. Bone Joint J. 2020 Aug;102-B(8):967-980. doi: 10.1302/0301-620X.102B8.BJJ-2019-1465.R1.

    Prognostic factors and survival in conventional chondrosarcoma: A single institution review. J Chin Med Assoc. 2020 Jul;83(7):669-673. doi: 10.1097/JCMA.0000000000000315.

    Adjuvant therapy by high-speed burr may cause intraoperative bone tumor seeding: an animal study. BMC Musculoskelet Disord. 2020 Jul 31;21(1):507. doi: 10.1186/s12891-020-03544-3.

    Proteomic profiling and identification of significant markers from high-grade osteosarcoma after cryotherapy and irradiation. Sci Rep. 2020 Feb 7;10(1):2105. doi: 10.1038/s41598-019-56024-7.

    Suboptimal outcomes after internal fixation for displaced intracapsular femoral neck fractures in 50- to 60-year-old patients. Hip Int. 2020 Jul;30(4):474-480. doi: 10.1177/1120700019859842. Epub 2019 Jun 23.

    The efficacy of continuous versus single-injection femoral nerve block in Total knee Arthroplasty: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2020 Feb 24;21(1):121. doi: 10.1186/s12891-020-3148-1.

    Low rates of all-cause revision in displaced subcapital femoral neck fractures treated with hip hemiarthroplasty - a retrospective review of 4516 patients from a single institute. BMC Musculoskelet Disord. 2020 Oct 22;21(1):700. doi: 10.1186/s12891-020-03725-0.

    Exploring the Proteomic Alterations from Untreated and Cryoablation and Irradiation Treated Giant Cell Tumors of Bone Using Liquid-Chromatography Tandem Mass Spectrometry. Molecules. 2020 Nov 16;25(22):5355. doi: 10.3390/molecules25225355.

    Is short-course systemic antibiotic therapy using an antibiotic-loaded cement spacer safe after resection for infected total knee arthroplasty? A comparative study. J Formos Med Assoc. 2020 Jun;119(6):1070-1079. doi: 10.1016/j.jfma.2019.10.001. Epub 2019 Oct 19.
  • 2019-12-31
    2019 SCI 醫學文章
    Expression profile‑driven discovery of AURKA as a treatment target for liposarcoma. Int J Oncol. 2019 Oct;55(4):938-948

    Suboptimal outcomes after internal fixation for displaced intracapsular femoral neck fractures in 50- to 60-year-old patients. Hip Int. 2019 Jun 23

    The efficacy of intraoperative periarticular injection in Total hip arthroplasty: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2019 Jun 1;20(1):269

    Bone morphogenetic protein activity preservation with extracorporeal irradiation- and liquid nitrogen freezing-treated recycled autografts for biological reconstruction in malignant bone tumor. Cryobiology. 2019 Aug;89:82-89.

    Analysis of learning curve of minimally invasive total knee arthroplasty: A single surgeon's experience with 4017 cases over a 9-year period. J Chin Med Assoc. 2019 Jul;82(7):576-583.

    The mid-term outcome of dialysis-dependent patients undergoing primary total knee arthroplasty and total hip arthroplasty: A retrospective study. J Chin Med Assoc. 2019 Feb;82(2):143-147

    Does continued aspirin mono-therapy lead to a higher bleeding risk after total knee arthroplasty? J Chin Med Assoc. 2019 Jan;82(1):60-65.
  • 2018-12-31
    2018 SCI 醫學文章
    Intraoperative Extracorporeal Irradiation and Frozen Treatment on Tumor-bearing Autografts Show Equivalent Outcomes for Biologic Reconstruction. Clin Orthop Relat Res. 2018 Apr;476(4):877-889.

    Does continued aspirin mono-therapy lead to a higher bleeding risk after total knee arthroplasty? J Chin Med Assoc. 2018 Sep 7. pii: S1726-4901(18)30229-6.

    Can imaging distinguish between low-grade and dedifferentiated parosteal osteosarcoma? J Chin Med Assoc. 2018 Oct;81(10):912-919

    Printing a 3-dimensional, Patient-specific Splint for Wound Immobilization: A Case Demonstration. Ostomy Wound Manage. 2018 Jul;64(7):28-33.

    A safety comparative study between freezing nitrogen ethanol composite and liquid nitrogen for cryotherapy of musculoskeletal tumors. Cryobiology. 2018 Aug;83:34-39.

    Optimal timing for elective total hip replacement in HIV-positive patients. Orthop Traumatol Surg Res. 2018 Sep;104(5):671-674.

    Cement augmentation in the proximal femur to prevent stem subsidence in revision hip arthroplasty with Paprosky type II/IIIa defects. J Chin Med Assoc. 2018 Jun;81(6):571-576.

    Alveolar soft part sarcoma: Clinical presentation, treatment, and outcome in a series of 13 patients. J Chin Med Assoc. 2018 Apr 3. pii: S1726-4901(18)30026-1.

    Grafting for bone defects after curettage of benign bone tumor - Analysis of factors influencing the bone healing. J Chin Med Assoc. 2018.

    Minimally Invasive Total Knee Arthroplasty: A Single Surgeon's Experience with 4107 Cases Over a Nine-Years Period. J Chin Med Assoc. 2018.
  • 2017-12-31
    2017 SCI 醫學文章
    Freezing Nitrogen Ethanol Composite may be a Viable Approach for Cryotherapy of Human Giant Cell Tumor of Bone. Clinical Orthopaedics and Related Research. CORR 2017 Jun;475(6):1650-1663.

    Early passage Mesenchymal Stem Cells display decreased radiosensitivity and increased DNA repair activity. Stem Cells Translational Medicine. 2017 Jun;6(6):1504-1514.

    Postoperative Ambulatory Performance Status Significantly Affects Implant Failure Rate Among Surgical Treatment Strategies in Patients With Proximal Femur Metastasis. Artif Organs. 2017 Jun;41(6):585-592.

    Prognosis-Based Shoulder Hemiarthroplasty After Resection of Proximal Humeral Malignancy. Artif Organs. 2017 Jul 19.

    Revision Total Knee Arthroplasty Using a Constrained Condylar Knee Prosthesis Combined with a Posterior Stabilized Articular Surface. J Knee Surg. 2017 May 23.

    Partial component-retained two-stage reconstruction for chronic infection after uncemented total hip arthroplasty: results of sixteen cases after five years of follow-up. Int Orthop. 2017 May 27.

    Generation of Osteosarcomas from a Combination of Rb Silencing and c-Myc Overexpression in Human Mesenchymal Stem Cells. Stem Cells Transl Med. 2017 Feb;6(2):512-526.

    Intralesional curettage of central low-grade chondrosarcoma: A midterm follow-up study. J Chin Med Assoc. 2017 Mar;80(3):178-182.

    Revision Total Knee Arthroplasty Using a Constrained Condylar Knee Prosthesis Combined with a Posterior Stabilized Articular Surface. J Knee Surg. 2018 Feb;31(2):197-201.
  • 2016-12-31
    2016 SCI 醫學文章
    Pathological fractures in predicting clinical outcomes for patients with osteosarcoma. BMC Musculoskelet Disord. 2016 Dec 28;17(1):503. Intralesional curettage of central low-grade chondrosarcoma: A midterm follow-up study. J Chin Med Assoc. Nov 23. S1726-4901(16)30196-4.

    Outcomes of 50 Patients With Ewing Sarcoma Family of Tumors Treated at a Single Institution in Taiwan. Medicine (Baltimore). 2016 May;95(22):e3830.

    Improvement in High-Grade Osteosarcoma Survival: Results from 202 Patients Treated at a Single Institution in Taiwan.. Medicine (Baltimore)., ;95(15):e3420.
  • 2015-12-31
    2015 SCI 醫學文章
    Etiologies and outcome of osteonecrosis of the femoral head: Etiology and outcome study in a Taiwan population.. J Chin Med Assoc. pii: S1726-4901(15)00205-1.

    Calcified Coracoacromial Ligament. Internal Medicine 54(14):1827 .July 2015

    Total Hip Arthroplasty for Patients Who Have Ankylosing Spondylitis: Is Postoperative Irradiation Required for Prophylaxis of Heterotopic Ossification?. J Arthroplasty. 2015 Oct;30(10):1752-6.

    Modified anterolateral approach in minimally invasive total hip arthroplasty. Hip Int. 2015 May-Jun;25(3):245-50.

    Zoledronic acid-loaded bone cement as a local adjuvant therapy for giant cell tumor of the sacrum after intralesional curettage. Eur Spine J. 2015 Oct;24(10):2182-8.

    Bone-prosthesis composite with rotating hinged-knee prosthesis in limb salvage surgery for high-grade sarcoma around the knee.. J Arthroplasty., 30(1):90-4.

    Acremonium species combined with Penicillium species infection in hip hemiarthroplasty: a case report and literature review.. Hip Int., 5;24(6):656-659.
  • 2014-12-31
    2014 SCI 醫學文章
    Population-based epidemiology of postoperative venous thromboembolism in Taiwanese patients receiving hip or knee arthroplasty without pharmacological thromboprophylaxis.. Thrombosis Research, 133(5):719-24.

    Manipulation therapy prior to diagnosis induced primary osteosarcoma metastasis--from clinical to basic research.. PLoS One, 7;9(5):e96571.

    Wake-up test in total hip arthroplasty with high-riding developmental dysplasia. Orthopedics., 37(7):e625-30.

    Nonpalpable intramuscular hemangioma treated with hookwire localization and excision.. J Chin Med Assoc., 77(8):426-9.
  • 2013-12-31
    2013 SCI 醫學文章
    Pulmonary embolism following total knee arthroplasty in Taiwanese patients.. Journal of the Chinese Medical Association, S1726-4901(13)00311-0.

    Osteomyelitis of the femur mimicking bone tumors: a review of 10 cases.. World Journal of Surgical Oncology, 11(1):283.

    Osteoblastoma in the region of the hip.. Journal of the Chinese Medical Association., 76(2):115-20.
  • 2012-12-31
    2012 SCI 醫學文章
    Simultaneous Anterior and Posterior Synovectomies for Treating Diffuse Pigmented Villonodular Synovitis.. Clinical Orthopaedics and Related Research.

    No significant squeaking in total hip arthroplasty - A series of 413 hips in the Asian people. . Journal of Arthroplasty, 27，P.1575P.1579.

    Extensively porous-coated stems for femoral revision: reliable choice for stem revision in Paprosky femoral type III defects.. Orthopedics, 35(7):e1017-21.

    Clinical outcomes and prognostic factors of Ewing sarcoma: a clinical analysis of 12 patients in Taiwan.. Journal of the Chinese Medical Association, 75，P.16-P.20.
  • 2011-12-31
    2011 SCI 醫學文章
    Primary osteogenic sarcoma with pulmonary metastasis: clinical results and prognostic factors in 91 patients. Japanese Journal of Clinical Oncology, 39，P514-P522).

    The prognosis for patients with osteosarcoma who have received prior manipulative therapy.. Journal of Bone & Joint Surgery, British Volume, 92，P.1580-P.1585.

    In Brief: arthroplasty in developmental dysplasia of the hip.. Clinical Orthopaedics and Related Research., 468，P.3426-P.3427.

    Pelvic hemophilic pseudotumor presenting as severe sciatic pain in a patient with no history of hemophilic symptoms.. Journal of Orthopaedic Science.

    High-grade osteosarcoma treated with hemicortical resection and biological reconstruction.. Journal of Surgical Oncology, 105，P.825-P.829.

    The prognosis of patients with primary osteosarcoma who have undergone unplanned therapy.. Japanese Journal of Clinical Oncology, 41，P.1244-1250.